A new approach to metabolite compartmentation in muscle.

measures total flux whereas the incorporation of acetate may reflect events essentially unconnected with the rate of cholesterogenesis, we consider that the results obtained in vivo are more representative of physiological events. The conclusion from the present experiments therefore confirms the one made in the preceding paper. That is, cholesterogenesis in the rat at the principal sites, liver and small intestine, is not subject to diurnal variation under normal conditions.